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Genetic and environmental factors also disrupt the symbiotic interaction by altering the microbial composition, distribution and the metabolic activity which may result in dysbiosis, a contributing factor for the onset and progression of several chronic diseases including cancer. Inter individual variations of micobiota of host are associated with each host genetics and environmental factors like diet, physical activity, stress, smoking, drugs, illness, and antibiotics. However these organisms interact with the host at multiple levels to maintain its normal functions. Disruptions in this complex ecosystem crosstalk result in physiological changes associated with colorectal tumour genesis as wells as cell proliferation, programmed cell death process and immune responses.
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