alexa Nicotinamide Phosphoribosyltransferase in Human Diseases

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Nicotinamide Phosphoribosyltransferase in Human Diseases

Nicotinamide phosphoribosyltransferase (NAMPT) was cloned by Samal and his colleagues in 1994 from activated human peripheral blood lymphocytes during their attempt to discover new factors for the earliest events in B-cell development [1]. The first NAMPT cDNA was screened out from those activated lymphocyte cDNA libraries using a degenerate oligonucleotide probe, which was designed on the basis of the similarity in the coding sequences of GM-CSF, IL-2, IL-1β, IL-6 and IL-13 at the signal peptidase processing site. NAMPT was initially named pre-B-cell colony enhancing factor (PBEF) after its function to promote pre-B-cell colony formation in the presence of stem cell factor plus interleukin 7.

Citation: Zhang LQ, Heruth DP, Ye SQ (2011) Nicotinamide Phosphoribosyltransferase in Human Diseases. J Bioanal Biomed 3: 013-025.

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