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Nicotinamide phosphoribosyltransferase (NAMPT) was cloned by Samal and his colleagues in 1994 from activated human peripheral blood lymphocytes during their attempt to discover new factors for the earliest events in B-cell development [1]. The first NAMPT cDNA was screened out from those activated lymphocyte cDNA libraries using a degenerate oligonucleotide probe, which was designed on the basis of the similarity in the coding sequences of GM-CSF, IL-2, IL-1β, IL-6 and IL-13 at the signal peptidase processing site. NAMPT was initially named pre-B-cell colony enhancing factor (PBEF) after its function to promote pre-B-cell colony formation in the presence of stem cell factor plus interleukin 7.
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