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As pressure increases to reduce the use of opioids in treating pain, prescribers are looking for ways to treat pain with other types of medications and interventions, either alone or in combination. One option is targeted topical analgesics. Some of the most popular of these medications are non steroidal anti-inflammatory drugs (NSAIDs) in liquid, gel, or patch formulations. The relatively easy application and the decreased potential for side effects with topical NSAIDs have made them a more desirable option when patients present with acute pain.