alexa BTF3-Promoter Based Screening of Anti- Human Breast Cancer Compounds

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BTF3-Promoter Based Screening of Anti- Human Breast Cancer Compounds

Breast cancer is one of the most frequently diagnosed forms of metastasis in women worldwide and ranks second after lung cancer  Studies performed in year 2014 revealed more than 3.1 million breast cancer cases in U.S women . Nearly 458,000 deaths per year from breast cancer were reported making it the most common cause of female cancer death in both the developed and developing world. BTF3 (Basic Transcription Factor 3), is a 27 kDa protein, first studied in HeLa cell where it was discovered as a general transcription factor and its role was defined in transcription initiation by RNA polymerase B from proximal promoter elements such as TATA box and CAAT box sequences. Apart from its role in Transcription, later studies revealed that BTF3 is also involved in protein regulation during translation and is therefore also known as Nascent- polypeptide associated complex β-subunit (βNAC) [6]. BTF3 has been studied for its importance embryonic development in mouse embryos, where mice homozygous for mutant allele died after 6.5 embryonic day post implantation.

 Rawat K, Haq W, Tripathi RK (2015) BTF3-Promoter Based In Vitro Screening of Anti- Human Breast Cancer Compounds. Clin Exp Pharmacol 5:183.

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