African American women experience elevated risk for breast and cervical cancer compared to White women. Health risk behaviors and cancer screening practices are known to contribute to cancer disparities; however, little is known about the relationship between race, sexual orientation, and cancer risk. The objective of this paper is to report on engagement in a range of health risk behaviors associated with cancer and adherence to cancer screening guidelines among African American Women sexual minority women. Methods: This was a cross sectional descriptive study. Data were collected using a self-administered survey instrument. Participants (N=226) were a convenience sample of urban African American sexual minority women recruited as part of a community health needs assessment study. Results: Cancer risk behaviors were prevalent including high rates of obesity, physical inactivity, tobacco and alcohol use.