Acute Postoperative Hypertension (APH) is one of the most common complications detected after surgery. It is a condition associated to a great number of causes and a pathophysiology still unclear which recognizes a central role in sympathetic activation. For these reasons, an ideal agent for treating APH does not exist, but have to choose the most appropriate therapeutic strategy based on the individual case.
The pathophysiologic mechanism underlying APH is depending by patient’s general condition, surgery and anesthesia. The most common APH risk factor, is a lack of preoperative intake of antihypertensive drugs scheduled, in patients already suffering from chronic arterial hypertension. Additional conditions favoring the hemodynamic instability are: massive infusion of fluids in perioperative time and all the conditions of physical stress generating an overactive Sympathetic system (hypoxia, anxiety, pain, etc.)