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Atherosclerosis represents the leading cause of morbidity and mortality in industrialized countries. It was initially defined as a process caused by the passive accumulation of lipids in the vessel wall, whereas nowadays it is considered as a complex condition where multiple pathogenic factors contribute to trigger and sustain vessel wall damage. Experimental studies have clearly demonstrated that atherosclerosis is a progressive inflammatory process that frequently affects large- and medium-sized arteries leading to cardiovascular diseases such as coronary heart disease (CHD) and stroke.
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