Tadalafil, Phosphodiesterase5 (PDE5) has a therapeutic effect on pulmonary hypertension (PH) and an amino acid citrulline expand arteries as an extracellular supplement to improve the production of Nitric Oxide (NO). Therefor it is assumed that combination of citrulline and tadalafil on monocrotaline (MCT) exerts a strong effect on Pulmonary Hypertension.

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Link:https://www.omicsonline.org/blog/2015/09/15/20356-Effect-of-Citrulline-Combined-with-Tadalafil-on-Monocrotaline--Induced-Pulmonary-Hypertension-in-Rats-Compared-with-Arginine.html

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