Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Yoichiro Yoshida
Mitochondria are the main sites of energy production in almost all eukaryotic cells. Mitochondria use oxidative phosphorylation to convert redox energy of substrates into adenosine triphosphate (ATP). Mitochondrial transcription factor A (mtTFA; also known as TFAM) is necessary for both transcription and maintenance of mitochondrial DNA (mtDNA), and it is one of the high mobility group (HMG) proteins that preferentially recognizes cisplatin-damaged DNA and oxidized DNA. Loss of mtTFA causes depletion of mtDNA, loss of mitochondrial transcripts, loss of mtDNA-encoded polypeptides, and severe respiratory chain deficiency. Mitochondria play a critical role in cancer cell metabolism and are also essential for cell proliferation. It is well known that mitochondrial uncoupling mediates the metabolic shift to aerobic glycolysis in cancer cells. Thus, mitochondria control cell survival and growth. In addition, the number of mitochondria correlates with the growth rate of cancer cells. The information gleaned from this review may provide critical clues to novel therapeutic interventions aimed at overcoming cancer.
You can submit articles in our peer reviewed Journal at http://scitechnol.com/submitmanuscript.php
Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi