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The term "antiphospholipid syndrome" has been proposed to describe the association of arterial and venous thrombosis, recurrent fetal loss, and immune thrombocytopenia with a spectrum of autoantibodies directed against cellular phospholipid components. Because of the antigen spesificity of antiphospholipid antibodies (aPL) and the pathophysiology of thrombosis in antiphospholipid syndrome (APS) are heterogeneous and multifactorial, a single scenario cannot explain the mechanisms of thrombophilia or pregnancy morbidity in patients. Investigation of the clinical epidemiology of APS is in its early stages.
Citation: Hancer VS (2011) Genetics of Antiphospholipid Syndrome. Human Genet Embryol 1:e103
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