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Repeated DNA sequences in the genome are subject to heteromorphism. Chromosomal heteromorphisms are structural chromosomal variants that are widespread in human populations and have no known effect on phenotype .These heteromorphic regions may be identified by several methods; each of these methods reveals a typical staining pattern implying constitutional differences in heterochromatin. Common chromosomal polymorphisms detected by Giemsa banding are considered as heteromorphisms and include heterochromatin regions on short arms of Acrocentric chromosomes and regions of chromosomes 1, 9, 16 and Y. Impact of chromosome heteromorphism has been studied previously on infertility and recurrent miscarriages.
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