The vast majority of LSPR sensors have been carried out based on the Au or Ag nanoparticles. Gold is often chosen because of its chemical stability. The Ag particles are more desirable because they have sharper resonances and higher refractive index sensitivity. Especially, in our previous work, we incorporated a suitable amount of gain material in core layer to improve the sensitivity of the goldshell silica–core nanoparticle for bio-molecular sensors. The gainassisted sensors have the powerful ability to detect a subtle change in the concentration of its background medium. The particle shape also plays an important role in determining the sensitivity.
Citation: : Ge C, Tao Y, Guo Z (2015) Biosensors Based on Plasmonics. Biosens J 4: 123.