alexa Thermal Analysis Methods in Pharmaceutical Quality Control

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Thermal Analysis Methods in Pharmaceutical Quality Control

Thermal analysis is defined as a group of physical‐chemical methods which the properties of studied material are measured as a function of temperature or time while the sample is placed under a controlled temperature program. The program may include heating or cooling (dynamic), or fixed temperature (isothermal), or a combination of these methods. Different multi-component techniques including thermogravimetry, differential thermal analysis, differential scanning calorimetry and thermo-microscopy are available instrumentally. Nowadays, these methods has gained significant attention in both quality control and functional research on Industries such as polymers, pharmaceuticals, metals and alloys. Thermogravimetry (TG) or Thermogravimetric analysis (TGA) is a fundamental laboratory instruments applied for investigation of the material properties in various fields such as pharmaceutical, environmental, food and petrochemical applications. TGA is a technique in which the amount of weight change of a substance, is monitored either as a function of controlled temperature, or isothermally as a function of time, in an atmosphere of N2, He, air, other gas, or in vacuum. The differential thermal analysis (DTA) is common thermal analysis method in which an analyte and an inert reference are heating at a certain heating rate while any temperature change is recorded. DTA is a popular tool used to characterize pharmaceuticals, foods, biologicals, organic and inorganic chemicals and briefly applied to measure endothermic and exothermic transitions as a function of temperature. Differential scanning calorimetry or DSC is a popular thermoanalytical technique ranging from the pharmaceutical science to applied research. DSC monitors the difference in the amount of required heat to increase the temperature of a sample and reference (which should have an acceptable heat capacity in the range of scanned temperatures) as a function of temperature.

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