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Acute Coronary Syndrome [ACS] refers to a spectrum of clinical presentations ranging from those for ST-Segment Elevation Myocardial Infarction [STEMI] to presentations found in Non–ST-segment Elevation Myocardial Infarction [NSTEMI] or in unstable angina. In terms of pathology, ACS is almost always associated with rupture of an atherosclerotic plaque and partial or complete thrombosis of the infarct-related artery. In some instances, however, stable Coronary Artery Disease [CAD] may result in ACS in the absence of plaque rupture and thrombosis, when physiologic stress [e.g, trauma, blood loss, anemia, infection, and tachyarrhythmia] increases demands on the heart.
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