It is claimed that the importance of Chagas disease had not been become clear by 1912, and that for this reason the Karolinska Institute did not award the prize to Chagas. Nevertheless, it must be pointed out that Bruce had been indicated more than 30 times for the prize during the same period for having discovered only the etiology and the vector of a well-known disease: the sleeping sickness Therefore, I believe that Chagas did not win the Nobel Prize because he was working at the world periphery. The situation would be completely different in 1921. At that time, Chagas had established the principal characteristics of the new disease, highlighting the importance of heart disease as the dominant clinical picture as well as the importance of the disease from a socioeconomic viewpoint. Furthermore, Chagas had published their scientific works in the most important scientific European journals of the time, so that their works were certainly known by the members of the Nobel Committee of the Karolinska Institute.