alexa Nanoparticles for Superior Pharmacokinetics and Enhanced Efficacy

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Nanoparticles for Superior Pharmacokinetics and Enhanced Efficacy

 Solubility and permeability are the two most important factors that can significantly affect Pharmacokinetic (PK) properties of a drug molecule. The Biopharmaceutics Classification System (BCS) classify drug molecules based on solubility and intestinal permeability. Sufficient balance of hydrophilicity and lipophilicity is required for a drug to be absorbed well. Drugs which are highly soluble may be limited by permeability or vice-versa. Similarly, a highly soluble drug given by intravenous (IV) route may have undesirable distribution or clearance. The uses of nanoparticles have shown some promises in addressing these barriers to the usefulness of the drugs. Originally stemmed from the idea of increasing usefulness of existing small molecule anti-cancer agents, this method has gained popularity due to its ability to allow delivery of nucleic acids, peptides, or proteins for disease treatment [1]. Nanoparticles based drug delivery approach has enormous clinical significance as demonstrated by new nanoparticle based drug approvals like pegylated liposomes of doxorubicin. Altered distribution and slower excretion of this liposomal injection resulted in the area under curve (AUC) of doxorubicin hydrochloride liposome injection ~2-3 times more than the AUC for similar doses of conventional doxorubicin hydrochloride 

Citation: Deepak Gupta, Phoung Nguyen and Monica Yu (2014) Nanoparticles for Superior Pharmacokinetics and Enhanced Efficacy. J Dev Drugs 3:e137. doi: 10.4172/2329-6631.1000e137

 

 
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