alexa Pharmacogenomics in Drug Discovery and Development

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Pharmacogenomics in Drug Discovery and Development

 Mapping, sequencing and further decoding of human genome sequence in the last decade have completely revolutionized the drug discovery and development efforts. Out of ~3000 disease genes identified by human genome project, it has been estimated that ~500 are disease genes with druggable domains [1]. Currently marketed drugs only target <50% of these genes. This leaves us with hundreds of well-established but still under-utilized drug targets. It has been estimated that a drug with well-established target has much higher chances (~17%) of reaching preclinical development than a drug with not so established drug target (~3%) [2]. So, target identification and selection based on human genome sequence ensures much higher chances of success for the approval of a drug

Citation: Gupta D (2013) Pharmacogenomics in Drug Discovery and Development. J Develop Drugs 2:e126. doi: 10.4172/2329-6631.1000e126

 
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