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By 1945, researchers at Hoechst had isolated levo-methadone (a difficult and costly process), discovering it had a far greater analgesic activity over the racemic form [2]. By the late 1940s, USA-based Eli Lilly (who bought the methadone patent as war reparations for the peppercorn sum of $1) confirmed the analgesic superiority of levomethadone [3,4]. To date, levo-methadone has never been developed commercially in the U.S.A.
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