Translational research is meant to connection for the gap between basic research and the clinic in order to facilitate the transition of knowledge and discovery into therapeutics. However, because of current approach to translational research, there is still significant discordance between preclinical findings and clinical results. Such discordance has hindered the clinical impact of research. This trend is no longer viable. It’s time to break away from the state and build translational research. Doing so could enable therapeutic breakthroughs and drive up return on investment, which in turn would facilitate additional funding for research.