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It is estimated that most of the medicinal compounds developed during the 20th century have their origins in phenothiazines [1]. Among these medicinal compounds is the first neuroleptic chlorpromazine (CPZ) introduced in 1957. The wide use of CPZ resulted in many published observations that indicated activity against a wide variety of microorganisms that cause therapeutically problematic infections [2]. CPZ has been shown to have in vitro activity against antibiotic susceptible [3] and resistant strains of Mycobacterium tuberculosis [4], has cured the aortis monkey of an antibiotic resistant malaria infection [5] and has yielded a temporary cure of prion promoted CJD [6].
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