Biomolecules! The associations between them, is a variable, upon which are the structure and functions of living cells critically dependent. For the last few decades, researchers have been working on the dramatic advancement of understanding the non-covalent interactions of macromolecules and its role in the biological systems. Ligand-receptor interactions have become one of the most exciting and innovative research subjects in the most recent years. Receptors are referred to as the “molecular machinery” in which the ligand binds to activate or deactivate the machinery. The relationship between thermodynamics and kinetics of binding depends on the strength of binding and is related to the kinetics of ligand-receptor association and dissociation: how fast the ligand binds and how fast it dissociates [1]. Using X-ray and NMR techniques, which are important tools in explaining the molecular architecture, researchers have understood the ligand-receptor system which is of crucial importance for understanding how the ligand–protein or protein–protein interaction functions in the molecular machinery [2]. Moreover, simulation studies and various other techniques like atomic force microscopy, transducers, and biomembrane probes are also involved in analyzing and obtaining experimental information of ligand-receptor interactions [3].

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