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Meta Description: There is mounting evidence that asthma, COPD and PAH share important pathological features, including inflammation, smooth muscle contraction and remodeling.
Chronic inflammatory airway diseases such as bronchial asthma and chronic obstructive pulmonary disease (COPD) are major contributors to the global burden of disease. Pulmonary arterial hypertension (PAH) is a rare but life-threatening disease characterized by increasing pulmonary vascular resistance and progressive pulmonary hypertension that leads to right ventricular failure and death. There is mounting evidence that asthma, COPD and PAH share important pathological features, including inflammation, smooth muscle contraction and remodeling. A better understanding of the pathobiochemical mechanisms that causally involved in these multifactorial diseases can contribute to developing effective therapeutic strategies that target multiple genes and signal transduction pathways.
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