Immunodeficiency is a condition in which your body cannot produce enough substances to fight against an infection or a part of the immuneis missing. Immunodeficiency can also be defined as impairment of the immune response. In this condition the person is more prone to infections that are generally more severe and lasts longer as compared to the usual infections. Body’s main system in fighting against infections is immune system. We are born with innate immunity and adaptive immunity develops throughout the life. Immunodeficiency journals deals with immune response and diseases.