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Researchers and policymakers have increasingly acknowledged the role of community health workers to address clinical trials recruitment and retention challenges. The National Coalition of Hispanic Health and Human Services Organizations has described a critical need for the development and evaluation of infrastructure to meet the health needs of Latino communities, focusing on community-based services and sustainable efforts to reach the underserved. Community-based participatory research (CBPR) builds on the unique strengths and resources of communities to promote co-learning and capacity building, sharing and dissemination of data and knowledge, and the building of long-term commitments. CBPR approaches offer great promise for addressing disparities in clinical trials participation because they can engage untapped community resources and strengths, such as social networks, to enhance the involvement of communities in the cancer clinical trials enterprise.