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Notable interventions to overcome these barriers to clinical trial participation have emerged. Vicini et al. (2011) recently described a successful Community Clinical Oncology Program called Minority Outreach Program (MOP), which resulted in a 10-fold increase in annual minority patient clinical trial accruals. MOP included the development of a network of community-based organizations and a bilingual educational program to jointly promote knowledge about clinical trials. These approaches and their results suggest that the creation of a culturally sensitive environment in which to promote clinical trials participation may facilitate the recruitment of multi-ethnic populations. Another successful program, “Redes En Acción,” has established a cohort of Hispanic leaders and researchers to support community awareness studies around cancer clinical trials. By engaging the community in cancer research and education, this program has increased trials accrual and led to new programs for addressing cancer disparities.