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When establishing new diagnostic method for detection of the endothelial dysfunction in Rheumathoid arthritis (RA), it is necessary to compare the diagnostic values with other laboratory variables. The aim of this study is to determine the association between the asymmetric dimethylarginine (ADMA) and anti-cyclic citrullinated peptide antibodies (ACPA, Anti-CCP2) of the second generation in RA and to explain their connection in the process of citrulination of autoantigens in RA. Also, to determine the association between ADMA and the acute phase reactants: Rheumatoid factor (RF), C-reactive protein (CRP), as well as the index of disease intensity (DAS28) in early diagnosis in non-treated RA patients and to determine whether the amount of ADMA changes in the course of the evolution of disease. There was an association between ADMA and anti-CCP2 antibodies of the second generation in patients with RA.
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