Transcriptomics Inspires Long Noncoding RNA

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Transcriptomics Inspires Long Noncoding RNA

Now, the OMICS group has launched “Transcriptomics”, Open Access Electric Journal. Transcriptomics is one of young field of bioinformatics that deals with transcriptome, dynamics of transcripts, messenger RNA, ribosomal RNA, transfer RNA, small RNA like microRNA, and long noncoding RNA (lncRNA). Such kind of the field grows rapidly. Scientific outcomes of transcriptomics are divergent and flow swiftly. Therefore, the open access format fits the field well. One of remarkable achievements in transcriptomics is to identify noncoding RNA in the human genome. Coding regions of the human genome occupy less than 5% of the genome, while rest of the genome comprises noncoding regions that generate noncoding RNAs. Most of noncoding RNAs are categorized into lncRNAs (that are longer than two hundred nucleotides). More than 35,000 lncRNAs have been documented, while less than 180 lncRNAs have been annotated. We are focusing on a fraction of lncRNAs, bound with RNA binding protein TLS. Our deep sequencing analysis of the TLS-bound fraction of RNA indicated that approximately 5,000 lncRNAs bind to TLS. Many of these lncRNAs could possess biological function, because the RNAs bound to TLS have been found to induce repression of transcription.

citation: Kurokawa R (2013) Transcriptomics Inspires Long Noncoding RNA. Transcriptomics


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