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The U.S. Food and Drug Administration has approved roughly two dozen drugs for breast cancer treatment, but only a few predictivebiomarkers are currently available to guide their use. For example, levels of the estrogen or progesterone receptor have been found to predict sensitivity to compounds that interfere with estrogen receptor signaling, and, the over-expression of human epidermal growth factor receptor 2 (HER2) predicts sensitivity to pertuzumab, trastuzumab and lapatinib. Additional biomarkers would be of significant value for determining the sensitivity of tumors to drugs already approved for clinical use in breast cancer, as well as for new drug development [1,2].
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