Targeting therapy in Epidermal growth factor

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Targeting therapy in Epidermal growth factor

The Epidermal Growth Factor Receptor (EGFR), or ErbB1, is a member of the ErbB family of tyrosine kinase receptors. It is a 170 kDa transmembrane glycoprotein that can bind a variety of ligands on its extracellular domain, most notably Epidermal Growth Factor (EGF). Binding of ligand induces homo- or heterodimerization with a second EGFR molecule or another member of the ErbB family, respectively. Once dimerized, the molecule undergoes auto-phosphorylation on intracellular tyrosine residues. Phosphorylation of these tyrosine residues allows for recruitment of ATP to the catalytic kinase domain of EGFR, which allows for phosphorylation of effector molecules.

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