Non-small cell carcinomas represent the majority of cases, and encompass a broad range of histologic and molecular phenotypes that include squamous cell carcinoma, adenocarcinoma and large cell carcinoma. Prognosis is relatively poor even for early stage non-small cell carcinoma (NSCLC), with Stage IA and IB 5 year survival reported to be 71.25% and 57% respectively . Understanding the biology and metabolism of tumor cells helps determine factors related to tumor progression and spread, identifies potential new treatment targets and may help stratify patients to guide therapy.
Citation: Serfin J, Carragher J, Groman A, Dexter EU, Yendamuri S (2011) Outcome Prediction Using Markers of Aerobic Glycolysis (the Warburg effect) Varies Between Tumor Regions in Stage I Non-Small Cell Lung Cancer. J Mol Biomark Diagn 2:116.