The purpose of this paper is to investigate the measurement uncertainty of blade surface by coordinates measuring machines (CMMs). In the past, the measurement of blade surface by CMMs is usually measured in the vertical mode, of which the measuring probe is normal to the surface. In this paper, a rotation mode, of which the measuring probe of CMMS is not collinear with the normal of the blade surface, is presented and its feasibility is explored in measuring the blade surface. The measurement uncertainty of rotation mode by CMMs is also examined. It is found that the measurement uncertainty of the blade back is superior to that of the blade basin. Furthermore, the uncertainty at the blade bottom is inferior to that of the blade tip. The reason may be that the measurement accuracy is closely related with the surface curvature at different parts of the blade.