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Two Sides of the Same Coin?” which was published in Cancer Cell. In this review, the authors discuss the role and the weight of genetics and epigenetics in tumorigenesis. According to them “intriguing evidences have emerged showing that genetic and epigenetic mechanism are not separate events in cancer” and “alterations in epigenetic mechanisms can lead to genetic mutations, and genetic mutations in epigenetic regulators lead to an altered epigenome”.
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