Meta Description: Inflammation is the product of an independent innate immune system closely linked to the adaptive immune system. The key mediators of inflammation are inflammatory cytokines.
Inflammation has often been considered to be a nonspecific response and to play a bridging role in the activation of adaptive immunity. However, it is now accepted that inflammation is the product of an independent innate immune system closely linked to the adaptive immune system. The key mediators of inflammation are inflammatory cytokines, as determined by multiple lines of evidence both in vitro and in vivo.
Because of the crucial role of inflammatory cytokines, such as tumor necrosis factor-α, in the pathogenesis of autoimmune disorders, anticytokine treatment has been developed as a therapy for rheumatoid arthritis, juvenile idiopathic arthritis, inflammatory bowel diseases and Kawasaki disease. Kawasaki disease is the most common systemic vasculitis syndrome, primarily affecting small to medium-sized arteries, more particularly the coronary arteries.
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