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Meta Description: Vitamin D deficiency is the main cause of rickets, though nutritional deficiency of calcium and phosphorous generates the same clinical picture. Refractory cases include rickets of Renal Tubular Acidosis, Hypophosphatemic rickets, and Vitamin D dependent Rickets.
Rickets is the most common form of metabolic bone disease in children. Vitamin D deficiency is the main cause of rickets, though nutritional deficiency of calcium and phosphorous generates the same clinical picture. Refractory cases include rickets of Renal Tubular Acidosis, Hypophosphatemic rickets, and Vitamin D dependent Rickets. Rickets is a disease of growing bone that is due to unmineralized matrix at the growth plates. Vitamin D deficiency is the most common cause of rickets, but any condition that disturbs bone mineralization can cause rickets. Rickets was first reported in the mid-1600s in Europe.
Gilson and others described typical findings of bone-deformity with curving of the legs. Rickets a disease of deficiency is still a common finding in the developing countries amongst the under 5 children, peak age of presentation is between the age 1-3 years, It is being contemplated that the basis of rickets in older children may be through another mechanism or the calcium deficiency which was also observed, not purely a nutritional deficiency.
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