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T4 Phage Surfaces
Bacteriophages (phages) are naturally occurring, obligate parasites about 25-200 nm in length that infect bacteria. They reproduce via a lysogenic or lytic cycle, the latter of which is commonly associated with bacterial lysis (death) and the release of viral progeny. In each case, the initial adsorption and binding of phage to target bacterial cells is multivalent, strong and highly specific, like antibodies but significantly cheaper since phage can be cultured with ease. As a consequence of their ubiquitous nature and general biocompatibility with non-target cells, the use of phage as nanobiosensors and biosorbents to capture, detect and identify bacteria is an active area of research
Citation: Khan MF, Dong H, Chen Y, Brook MA (2015) Low Discrimination of Charged Silica Particles at T4 Phage Surfaces. Biosens J 4:125.
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