Accurate diagnosis of LBP may be difficult and requires a comprehensive approach. However, the history and physical examination may elicit warning signals that indicate the need for further work-up and treatment. These "red flags" include a history of trauma, fever, incontinence, unexplained weight loss, a cancer history, long-term steroid use, parenteral drug abuse, intense localized pain and back pain that is increased or unrelieved by rest.

Citations: Jang-Chun L, Jo-Ting T, Hsin-I M, Wei-Hsiu L (2015) Low Back Pain Radiating to the Left Buttock as a Form of Onset of Multiple Myeloma: A Rare Case Report. Curr Synthetic Sys Biol 3:119.

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