Vibrio cholarae is the causative agent of cholera. It is responsible behind a variety of diseases specifically the multidrug-resistant nosocomial infections and chronic lung infections in cystic fibrosis patients. One of the vital genes of the organism responsible for its multidrug resistant behaviour is the gene PA3523 which codes for the multidrug efflux transporter. The expression of PA3523 is regulated by the dimeric transcription factor Lrp having Helix-Turn-Helix DNA binding motif. So far there have been no previous reports that depict the characterization of Lrp protein from Vibrio cholerae from a structural point of view. In the present work, an attempt has been made to characterize Lrp protein by structural bioinformatics approach.
Citations: Bagchi A (2014) Characterization of the Leucine-Responsive Transcription Factor from Pathogenic Vibrio cholerae Using Molecular Modelling and Molecular Dynamics Simulations. Curr Synthetic Sys Biol 2:110.