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The effects of draft tube structure on the performance of pilot-scale Internal Loop Airlift Reactors (IL-ALRs) were investigated by Computational Fluid Dynamic (CFD) simulations and experiments. The Euler-Euler two fluid model and the κ-ε turbulence model were adopted in the CFD model to predict the influence of draft-tube structure on the key flow parameters including gas holdup, gas distribution and liquid circulation velocity.