Aloe vera gel extract (AVGE) was recently produced using a new procedure with supercritical carbon dioxide fluid. AVGE was proven safe in acute toxicity and subchronic toxicological tests, and was shown to contain five phytosterols (Aloe-sterols). AVGE may inhibit the accumulation of visceral fat due to the functions of Aloe-sterols, which may, in turn, contribute to preventing metabolic syndrome. A meta-analysis previously revealed that obesity was positively associated with colon cancer. Therefore, we examined the effects of the dietary administration of AVGE on intestinal polyp formation in Apc-deficient Min mice fed a high-fat diet (HFD).

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