alexa Comprehensive Two-Dimensional Liquid Chromatography in Metabolome Analysis

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Comprehensive Two-Dimensional Liquid Chromatography in Metabolome Analysis

Metabolomics deals with analysis of highly complex biological samples resulting in insufficient separation of relevant metabolites from matrix substances with one-dimensional liquid chromatography. Comprehensive twodimensional liquid chromatography (2D-LC) is a promising technique for the analysis of complex samples because of its increased peak capacity. Comprehensive 2D-LC-MS/MS has been applied for a targeted metabolomics approach regarding metabolites from RNA catabolism. Combination of a Zorbax Eclipse Plus C18 column with a Zorbax Bonus-RP column resulted in increased peak capacity, minimisation of matrix effects and excellent reproducibility.

 

Citation: Willmann L, Schlimpert M, Pan D, Bauer C, Trafkowski J, et al. (2015) Comprehensive Two-Dimensional Liquid Chromatography in Metabolome Analysis. J Chromatogr Sep Tech 6:288. doi:10.4172/2157-7064.1000288

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