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HLA-B27 and an Electrocardiographic Peculiarity
In 1973 the strong association between the immunogenetic marker HLA-B27 and ankylosing spondylitis was described. More than 11 subtypes or polymorphisms of HLA-B27 have been described since, each one varying in frequency in different ethnic groups, with HLA-B 2705 the so-called "parent" allele, common in all racial groups. It was subsequently realized that HLA-B27 is common to the entire spectrum of seronegative spondyloarthropathies, such as ankylosing spondylitis, Reiter`s syndrome, psoriatic spondylitis, spondylitis in association with inflammatory bowel disease, juvenile spondyloarthropathy, undifferentiated spondyloarthropathy and acute anterior uveitis. This spectrum can range from the majority of individuals who have no disease at all to isolated skin, eye or joint involvement to full-blown ankylosing spondylitis.
HLA-B27 and an Electrocardiographic Peculiarity
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