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Test of potential agents in vitro and in faithful animal cancer models that relies on investigator-initiated testing on optimized in vitro systems, usually followed by further testing in the animal models core for orthotopic cell line and human tumor sample xenograft testing and the MP1U for testing in faithful genetically engineered murine models (GEMMs). Pharmacology and Pharmacogenetics includes investigators studying the pharmacology and pharmacodynamics of novel therapeutics, and well as investigators focusing on the genetics of drug toxicity in humans.
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