Carpal tunnel syndrome (CTS) is the most common compressive neuropathy in the upper extremity. The American Academy of Orthopaedic Surgeons (AAOS) Clinical Guideline on the Diagnosis of Carpal Tunnel Syndrome defines CTS as a symptomatic compression neuropathy of the median nerve at the level of the wrist, characterized physiologically by evidence of increased pressure within the carpal tunnel and decreased function of the nerve at that level.

Study implemented a cross-sectional data analysis and therefore did not allow for a temporal comparison of hand volume. Future studies should measure hand volumes before and after the onset of CTS. This would circumvent the need to compare one’s hand to the contralateral side as a form of baseline information, therefore reducing the limitations caused by handedness, deformity and bilateral disease. It also would provide multiple data points, thereby increasing the chance of detecting swelling in a waxing and waning disease course.

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