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The cell-cell adhesion is a fundamental phenomenon as well as intrinsic property of cell. Cell adhesion can be formed through four classes of junctions, viz., adherens junction, desmosomal junction, gap junction, and tight junction. The adherens junction and desmosomal junctions are mediated by cadherin and cadherin-like molecules that provide resistance to the shearing force to the neighboring cells. The gap junction is formed by connexin channels that form conduits between partnering cells to transfer small molecules less than molecular weight 1 kD.
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