The physical and physiological effects of local modulated electro-hyperthermia (mEHT) concentrates on the energy absorption of cluster rafts of the plasma membrane. The targeted cluster contains transmembrane proteins, which can form coherent working voltage-gated ion channels and/or TRP receptors in one domain.

This targeting is analogous to nanoparticle heating, except this uses readily available nanoparticles on the cell membrane instead of the artificially placed nano-object to induce selective energy absorption from the outside field.

You can explore more at: https://www.omicsonline.org/ArchiveBLM/articleinpress-biology-and-medicine-open-access.php

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