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Meta Description: The pharmacological action of glucocorticoids include opposing insulin action, decreasing glucose utilization, increase protein breakdown and activation of lipolysis thereby providing amino acids and glycerol for gluconeogenesis.
Glucocorticoids have profound effect on carbohydrate metabolism, stimulating the production of glucose from amino acids and glycerol in the liver. The pharmacological action of glucocorticoids include opposing insulin action, decreasing glucose utilization, increase protein breakdown and activation of lipolysis thereby providing amino acids and glycerol for gluconeogenesis. The production of extra insulin occurs in most people on steroids to counteract the hyperglycemic effect of steroids, however those who lack this ability, develop hyper glycaemia.Glucocorticoids are frequently prescribed drugs in various disease conditions. Nearly half of the patients treated with Glucocorticoids for more than two weeks developed a deranged glucose metabolism and those with risk factors for diabetes mellitus present with frank diabetes mellitus which is equivalent of an unmasked type 2 diabetes mellitus.
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