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Cellular senescence of endothelial cells plays an important role in the development of vascular lesions that ultimately lead to an atherosclerotic plaque. Age-related changes of endothelial and vascular smooth muscle cells also contribute to vascular disease that may act as potential new targets that could rejuvenate the vascular system and thereby prevent or delay atherosclerosis.
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Source: http://www.ncbi.nlm.nih.gov/pubmed/26634025
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