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Researchers from the Cancer Research Center of Toulouse have conducted the first comprehensive review on dendrogenin A (DDA). DDA is a steroidal alkaloid arising from cholesterol and histamine cross-metabolization that they recently discovered. Importantly, they found that DDA is a tumor suppressor metabolite.
Thus 100 years after the discovery of all-trans-retinoic acid, DDA appears as a rare example human metabolite promised to extensive basic research studies and clinical developments.
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