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Glucagon-like peptide 1 (GLP-1) is a gut-derived incretin hormone secreted in response to nutrients. GLP-1 is used in the therapeutic management of diabetes because of its gluco-regulatory effects, including augmentation of glucose-stimulated insulin secretion, suppression of postprandial glucagon secretion, delayed gastric emptying, and hypothalamus-mediated satiety of appetite. GLP-1 receptors are expressed not only in islet cells, kidney, lung, brain, and gastrointestinal tract, but also in the heart.
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