As it's known a lot of chemical substances of a different types are released to the environment and they form a big dangerous for living organisms. To prevent such threats there is necessary to provide continuously monitor not only the level of overall toxicity of the environment, but also to control the degree of stress on the genetic apparatus of living organisms, determining genotoxicity of various unfavorable factors, including various anthropological effects. The total toxicity may be determined with the participation of living organisms. In this review some most applicable methods with the using number of sensitive objects such as Daphnia sp., bioluminescent bacteria and plants are considered at the control of the total toxicity of environmental factors.

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